To assess the hypotensive efficacy of 5 antihypertensive drugs, i.e. ramipril, nitrendipine, manidipine, enalapril and nifedipine GITS(Gastrointestinal Therapeutic System), two ABP (Ambulatory blood pressure) recordings were obtained before and
after
treatment.
Data were analyzed for 24 hour mean, night time, day time, mean arterial pressure and % elevated blood pressure, and compared with CBP(clinic blood pressure). There were large discrepancy between CBP and ABP. In conclusion. ABP monitoring is more
correct and reliable method in evaluating antihypertensive efficacy of many drugs; by eliminating placebo effect, reducing sample size, selecting proper patient. Furthermore it exerts maximal merit in evaluation of night-time blood pressure
change
which
is critical for prevention of cardiovascular events during night and in the early morning.
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